Bioactivity:

Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 an

CAS nr:

875320-31-3

Purity:

98%

Molecular Weight:

467,39

SMILES:

Cl.Cl.CN1C=C(CNCC2CCN(CC2)C2=NC=C(C=N2)C(=O)NO)C2=CC=CC=C12

Formula:

C21H28Cl2N6O2

Pathway:

DNA Damage/DNA Repair,Chromatin/Epigenetic,Autophagy,Apoptosis

Target:

HDAC,HDAC,Autophagy,Apoptosis