Bioactivity:

Cucurbit[8]uril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbit[8]uril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbit[8]uril can induce energy transfer [1][2]. Cucurbit[8]uril (0~20 _M; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2].Cucurbit[8]uril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1]. Cucurbit[8]uril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice[2]. [1]. Uhlenheuer DA, et al. Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins. Chem Commun (Camb). 2011;47(24):6798-6800.[2]. Uzunova VD, et al. Toxicity of cucurbit[7]uril and cucurbit[8]uril: an exploratory in vitro and in vivo study. Org Biomol Chem. 2010;8(9):2037-2042.

CAS nr:

259886-51-6

Purity:

98%

Molecular Weight:

1329,12

SMILES:

O=C1N2CN3[C@H]4[C@H]5N(CN6[C@H]7[C@H]8N(CN9[C@H]%10[C@H]%11N(CN%12[C@H]%13[C@H]%14N(CN%15[C@H]%16[C@H]%17N(CN%18[C@H]%19[C@H]%20N(CN%21[C@H]%22[C@H]%23N(CN1[C@H]1[C@@H]2N2CN4C(=O)N5CN7C(=O)N8CN%10C(=O)N%11CN%13C(=O)N%14CN%16C(=O)N%17CN%19C(=O)N%20CN%22C(=O)N%23CN1C2=O)C%21=O)C%18=O)C%15=O)C%12=O)C9=O)C6=O)C3=O

Formula:

C48H48N32O16

Pathway:

Target: