Bioactivity:

Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively.

CAS nr:

1940206-71-2

Purity:

98%

Molecular Weight:

476,53

SMILES:

CN1C=NC2=CC(OC3=CC=CC=C3N4C(C)=CC5=C4C=C(NC6=NC=CC(NC)=N6)C=C5)=CN=C21

Formula:

C27H24N8O

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase