Bioactivity:

Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8/11 (IC50: 733/432 nM), and shows no effect on HDAC4/5/6/7/9.

CAS nr:

1616493-44-7

Purity:

98%

Molecular Weight:

390,41

SMILES:

Nc1cc(F)ccc1NC(=O)c1ccc(CNC(=O)\C=C\c2cccnc2)cc1

Formula:

C22H19FN4O2

Pathway:

DNA Damage/DNA Repair,Chromatin/Epigenetic

Target:

HDAC,HDAC