Bioactivity:

CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.

CAS nr:

2366237-37-6

Purity:

98%

Molecular Weight:

462,57

SMILES:

FC1=CN=C(NC2=NC=C(N3CC4(CN(CC)C4)C3)C=C2)N=C1C5=C([C@H](C)CCCC6)N6N=C5

Formula:

C25H31FN8

Pathway:

Cell Cycle/Checkpoint

Target:

CDK