Bioactivity:

GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.

CAS nr:

1362151-42-5

Purity:

98%

Molecular Weight:

460,43

SMILES:

O=C(NCC1=CC=C(S(=O)(C2=CC(C(F)(F)F)=CC=C2)=O)C=C1)C3=CC(C=NN4)=C4N=C3

Formula:

C21H15F3N4O3S

Pathway:

Metabolism

Target:

NAMPT