Bioactivity:

1-Hydroxyanthraquinone is an anthraquinone that has been found inMorinda officinalisand has genotoxic and carcinogenic activities.1,21-Hydroxyanthraquinone (5 and 500 _M) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.1Dietary administration of 1-hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats. 1.Kawai, K., Mori, H., Sugie, S., et al.Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinonesCell Biol. Toxicol.2(4)457-467(1986) 2.Mori, H., Yoshimi, N., Iwata, H., et al.Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasmsCarcinogenesis11(5)799-802(1990)

CAS nr:

129-43-1

Purity:

98%

Molecular Weight:

224,215

SMILES:

Oc1cccc2C(=O)c3ccccc3C(=O)c12

Formula:

C14H8O3

Pathway:

DNA Damage/DNA Repair,Cell Cycle/Checkpoint

Target:

DNA/RNA Synthesis,DNA/RNA Synthesis