Bioactivity:

A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).

CAS nr:

1235034-55-5

Purity:

98%

Molecular Weight:

669,79

SMILES:

CN(C)CC#Cc1cc(c(cc1)OCCCc1c(nc(s1)N1CCc2cccc(c2C1)C(=O)Nc1nc2ccccc2s1)C(=O)O)F

Formula:

C35H32FN5O4S2

Pathway:

Apoptosis

Target:

BCL