Bioactivity:

Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-_B, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-_B. Nimbolide is a triterpene derived from the leaves and flowers

CAS nr:

25990-37-8

Purity:

98%

Molecular Weight:

466,52

SMILES:

C[C@]12[C@@]3([H])[C@](OC([C@@]3(C=CC2=O)C)=O)([H])[C@]4([H])[C@]([C@@H]1CC(OC)=O)(C5=C(C)[C@@](C6=COC=C6)([H])C[C@@]5([H])O4)C

Formula:

C27H30O7

Pathway:

NF-_b,Apoptosis,Cell Cycle/Checkpoint

Target:

NF-_B,Apoptosis,CDK