Bioactivity:

Aftin-4, an amyloid forty-two inducer, activates _-secretase, promoting the generation of amyloid-_-1-42 (A_1-42) from amyloid-_ protein precursor. Aftin-4 increased A_-1-42, but not A_-1-40 in mouse hipppocampus, accompanied by learning deficits and mito

CAS nr:

866893-90-5

Purity:

98%

Molecular Weight:

368,48

SMILES:

CC[C@H](CO)Nc2nc1c(ncn1C(C)C)c(n2)N(C)Cc3ccccc3

Formula:

C20H28N6O

Pathway:

Stem Cells,Proteases/Proteasome,Neuroscience,Neuroscience

Target:

Gamma-secretase,Gamma-secretase,Gamma-secretase,Beta Amyloid