Bioactivity:

Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110_ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.

CAS nr:

934493-76-2

Purity:

98%

Molecular Weight:

270,29

SMILES:

CCN1C(=O)C(=CC2=C(C)N=C(N)N=C12)C1=CC=NN1

Formula:

C13H14N6O

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair

Target:

PI3K,mTOR,DNA-PK,DNA-PK