Bioactivity:

GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).

CAS nr:

1936422-33-1

Purity:

98%

Molecular Weight:

525,59

SMILES:

O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC

Formula:

C27H33F2N7O2

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain