Crenigacestat T3633
Specifications
| 1mg/5mg/10mg/25mg/50mg/100mg |
Bioactivity:
LY3039478 is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. LY3039478 effectively inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited expression of Notch-regulated
CAS nr:
1421438-81-4
Purity:
98%
Molecular Weight:
464,44
SMILES:
C[C@@H](C(=O)N[C@H]1c2ccccc2c2c(nccc2)N(C1=O)CCO)NC(=O)CCC(F)(F)F
Formula:
C22H23F3N4O4
Pathway:
Stem Cells,Proteases/Proteasome,Neuroscience
Target:
Gamma-secretase,Gamma-secretase,Gamma-secretase
