Bioactivity:

Kobe0065 is a novel and effective small-molecule compound inhibiting Ras�Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras�GTP to c-Raf-1 RBD with a Ki value of 46 � 13 _M.

CAS nr:

436133-68-5

Purity:

98%

Molecular Weight:

449,79

SMILES:

Cc1c(Cl)cc(NC(=S)NNc2c(cc(cc2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-])cc1

Formula:

C15H11ClF3N5O4S

Pathway:

MAPK,MAPK,GPCR/G Protein,Apoptosis

Target:

Raf,Ras,Ras,Apoptosis