Bioactivity:

GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2_nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M pha

CAS nr:

1196504-54-7

Purity:

98%

Molecular Weight:

414,73

SMILES:

O=C(C1CC1)NC2=CNC3=NC=C(Br)C(N4C[C@H](N)CCC4)=C32.[H]Cl

Formula:

C16H21BrClN5O

Pathway:

Cell Cycle/Checkpoint

Target:

Chk