Bioactivity:

PG01 is effective on _F508 (Ka of 0.3 _M). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases _F508-CFTR Cl- current after adding Forskolin. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R, and G551D (CF

CAS nr:

853138-65-5

Purity:

98%

Molecular Weight:

439,55

SMILES:

O=C(N(C)C(C1=CC=CC=C1)C(NC2=CC=C(C(C)C)C=C2)=O)CC3=CNC4=C3C=CC=C4

Formula:

C28H29N3O2

Pathway:

Membrane transporter/Ion channel

Target:

CFTR