Bioactivity:

JND3229 is a highly potent and fourth-generation EGFRC797S reversible inhibitor (IC50: 5.8 nM). It also effectively suppressed EGFRL858R/T790M and EGFRWT (IC50: 30.5 and 6.8 nM).

CAS nr:

2260886-64-2

Purity:

98%

Molecular Weight:

617,18

SMILES:

CC1=CC(NC2=NC(N([C@@H]3CC[C@@H](NC(CC)=O)CC3)C(N(C4=C(Cl)C=CC=C4)C5)=O)=C5C=N2)=CC=C1N6CCN(C)CC6

Formula:

C33H41ClN8O2

Pathway:

Others

Target:

Others