Bioactivity:

AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1]. AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sod

CAS nr:

1642112-31-9

Purity:

98%

Molecular Weight:

543,93

SMILES:

O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O

Formula:

C25H16ClF2N3O5S

Pathway:

Others

Target:

Others