Bioactivity:

Pentaacetylquercetin is a pentaacetylated derivative of the flavonoid quercetin that has diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in vitro (IC50 = 3.74 _g/ml) and inhibits iron(II) chloride-induced lipid peroxidation in rat liver mitochondria (IC50 = 20.2 _g/ml). Pentaacetylquercetin inhibits LPS-induced increases in nitrite (IC50 = 8.7 _M) and PGE2 production, as well as inducible nitric oxide synthase (iNOS) and COX-2 levels, in RAW 264.7 cells when used at concentrations of 20 and 40 _M. It also inhibits the growth of HL-60, U937, and SK-MEL-1 cells (IC50s = 38, 25, and 58 _M, respectively).

CAS nr:

1064-06-8

Purity:

98%

Molecular Weight:

512,423

SMILES:

CC(=O)Oc1cc(OC(C)=O)c2c(c1)oc(-c1ccc(OC(C)=O)c(OC(C)=O)c1)c(OC(C)=O)c2=O

Formula:

C25H20O12

Pathway:

Microbiology/Virology

Target:

RSV