Bioactivity:

KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFR_, IGF-1R, EGFR.

CAS nr:

1000669-72-6

Purity:

98%

Molecular Weight:

332,4

SMILES:

C1CN(CCN1)C(=O)c1ccc(cc1)/C=C/c1n[nH]c2ccccc12

Formula:

C20H20N4O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Chromatin/Epigenetic,Apoptosis,Tyrosine Kinase/Adaptors

Target:

FLT,FLT,Bcr-Abl,Bcr-Abl,Bcr-Abl,JAK,JAK,JAK,JAK,Aurora Kinase,Src,Src,FGFR,FGFR,Aurora Kinase,Apoptosis,c-Kit