Bioactivity:

ZX-29 is a potent and selective inhibitor of ALK(IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively), and also induces protective autophagy and has antitumor effect.

CAS nr:

2254805-62-2

Purity:

98%

Molecular Weight:

518,03

SMILES:

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=O

Formula:

C23H28ClN7O3S

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

ALK,ALK