Bioactivity:

AST 487 is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.

CAS nr:

630124-46-8

Purity:

98%

Molecular Weight:

529,56

SMILES:

CNc1cc(Oc2ccc(NC(=O)Nc3ccc(CN4CCN(CC)CC4)c(C(F)(F)F)c3)cc2)ncn1

Formula:

C26H30F3N7O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

FLT,FLT,VEGFR,VEGFR,c-RET,c-RET,c-Kit,Bcr-Abl,Bcr-Abl,Bcr-Abl