Bioactivity:

JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRv_ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).

CAS nr:

2305154-31-6

Purity:

98%

Molecular Weight:

376,18

SMILES:

Fc1c(Br)cccc1Nc1ncnc2cc3OCCOc3cc12

Formula:

C16H11BrFN3O2

Pathway:

JAK/STAT signaling,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

EGFR,EGFR,EGFR