Bioactivity:

NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 _M). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and ha

CAS nr:

444723-13-1

Purity:

98%

Molecular Weight:

422,52

SMILES:

CCN(CC)C(C(C=C1)=CC=C1NC2=NC(OCC3CCCCC3)=C4C(N=CN4)=N2)=O

Formula:

C23H30N6O2

Pathway:

Cell Cycle/Checkpoint,Cell Cycle/Checkpoint,Chromatin/Epigenetic

Target:

CDK,Aurora Kinase,Aurora Kinase