Bioactivity:

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 _M and >20 _M for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

CAS nr:

1473404-51-1

Purity:

98%

Molecular Weight:

402,81

SMILES:

S=C(N1N=C(C2=CC=C([N+]([O-])=O)C=C2)C(/N=N/C3=CC=CC(Cl)=C3)=C1O)N

Formula:

C16H11ClN6O3S

Pathway:

Tyrosine Kinase/Adaptors,Microbiology/Virology,Proteases/Proteasome,Tyrosine Kinase/Adaptors,Angiogenesis

Target:

Hck,HIV Protease,HIV Protease,Src,Src