Bioactivity:

Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP cells at 1 _M and 10 _M, respectiv

CAS nr:

1338812-36-4

Purity:

98%

Molecular Weight:

416,9

SMILES:

O=C(C1=CN(CCO)N=C1)N[C@H]2C(C)(C)[C@H](OC3=CC=C(C#N)C(Cl)=C3)C2(C)C

Formula:

C21H25ClN4O3

Pathway:

Others

Target:

Others