Bioactivity:

Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-_, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively.

CAS nr:

1019206-88-2

Purity:

98%

Molecular Weight:

500,83

SMILES:

O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1

Formula:

C21H17ClF4N4O4

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,MAPK,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Autophagy,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,Raf,VEGFR,VEGFR,c-RET,c-RET,Autophagy,c-Kit