Bioactivity:

Alofanib is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either

CAS nr:

1612888-66-0

Purity:

98%

Molecular Weight:

413,4

SMILES:

Cc1cc(c(NS(=O)(=O)c2cccc(c2)C(O)=O)cc1-c1cccnc1)[N+]([O-])=O

Formula:

C19H15N3O6S

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Apoptosis

Target:

FGFR,FGFR,Apoptosis