Bioactivity:

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 _M in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less s

CAS nr:

179237-49-1

Purity:

98%

Molecular Weight:

586,64

SMILES:

OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O

Formula:

C35H30N4O5

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors

Target:

FLT,FLT