Bioactivity:

4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells. 4-DPD (5 mg, i.p.) reduces lysyl oxidase activity by 26% and reduces collagen and elastin crosslinking, resulting in limb abnormalities in chick embryos. It decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy. 4-DPD reduces TNF-_ and IL-6 production in mice infected with T. spiralis.

CAS nr:

148-51-6

Purity:

98%

Molecular Weight:

189,64

SMILES:

Cl.Cc1ncc(CO)c(C)c1O

Formula:

C8H12ClNO2

Pathway:

GPCR/G Protein

Target:

S1P Receptor