Bioactivity:

RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.

CAS nr:

946128-88-7

Purity:

98%

Molecular Weight:

471,46

SMILES:

CNS(=O)(=O)NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F

Formula:

C21H18FN5O5S

Pathway:

MAPK,MAPK

Target:

Raf,MEK