Bioactivity:

TLI3-12 is the first small molecule degrader. It induces anaplastic lymphoma kinase (ALK) degradation, including that in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines.

CAS nr:

T34891

Purity:

98%

Molecular Weight:

961,49

SMILES:

O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O

Formula:

C45H53ClN10O10S

Pathway:

Target: