Bioactivity:

CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.

CAS nr:

405168-58-3

Purity:

98%

Molecular Weight:

419,91

SMILES:

[nH]1c(=O)c(c(c2cc(ccc12)Cl)N[C@@H]1CN2CCC1CC2)c1[nH]c2c(n1)cccc2

Formula:

C23H22ClN5O

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Stem Cells,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Apoptosis,Cell Cycle/Checkpoint

Target:

PDGFR,PDGFR,FLT,FLT,Src,GSK-3,GSK-3,Src,Apoptosis,Chk