Bioactivity:

SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and 70 nM, respectively).

CAS nr:

211096-49-0

Purity:

98%

Molecular Weight:

357,16

SMILES:

N#CC1=C(N=NN2)C2=C(C=C1)NC(NC(C=CC=C3)=C3Br)=O

Formula:

C14H9BrN6O

Pathway:

Immunology/Inflammation,GPCR/G Protein,Autophagy

Target:

CXCR,CXCR,CXCR