Bioactivity:

Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 _M in HLMs; Ki: 0.37 _M for rCYP2D6). It also inhibits HERG channel current.

CAS nr:

1394-48-5

Purity:

98%

Molecular Weight:

429,5

SMILES:

CC(=O)O[C@H]1C[C@@]2(CN3[C@@H]4[C@H]2[C@]5(C1)[C@H]3[C@]6(C([C@H]7[C@H]([C@@H]5[C@]6(C4)CC7=C)O)OC(=O)C)O)C

Formula:

C24H31NO6

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Metabolism,Membrane transporter/Ion channel,JAK/STAT signaling

Target:

HER,HER,P450,Potassium Channel,HER