Bioactivity:

Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic p

CAS nr:

1203586-72-4

Purity:

98%

Molecular Weight:

1200,36

SMILES:

Formula:

C48H73N13O17S3

Pathway:

Target: