Bioactivity:

Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM.

CAS nr:

19545-26-7

Purity:

98%

Molecular Weight:

428,43

SMILES:

CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

Formula:

C23H24O8

Pathway:

PI3K/Akt/mTOR signaling,Cell Cycle/Checkpoint,Metabolism,Microbiology/Virology,Cell Cycle/Checkpoint,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair,Autophagy

Target:

PI3K,Serine/threonin kinase,Serine/threonin kinase,Antibiotic,PLK,ATM/ATR,ATM/ATR,DNA-PK,DNA-PK,Autophagy