Bioactivity:

Cenisertib (AS-703569) is a multi-kinase inhibitor and blocks the activity of Aurora-kinase-A/B, AKT, ABL1, STAT5, and FLT3. Cenisertib inhibits tumor growth in xenograft models of breast, pancreatic, ovarian, colon, lung tumors, and leukemia.

CAS nr:

871357-89-0

Purity:

98%

Molecular Weight:

451,54

SMILES:

[H][C@@]1([C@H]([C@H]2C(N)=O)NC3=NC(NC4=CC=C(C(C)=C4)N5CCN(CC5)C)=NC=C3F)C[C@]2(C=C1)[H]

Formula:

C24H30FN7O

Pathway:

Stem Cells,JAK/STAT signaling,Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

STAT,STAT,Akt,Akt,Bcr-Abl,Bcr-Abl,Bcr-Abl