Bioactivity:

PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.

CAS nr:

952021-60-2

Purity:

98%

Molecular Weight:

419,48

SMILES:

Cn1cc(cn1)-c1[nH]c2cc(NC(=O)[C@H](N)C3CCCCC3)cc3c2c1cn[nH]c3=O

Formula:

C22H25N7O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Angiogenesis,Angiogenesis,Chromatin/Epigenetic,Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Cell Cycle/Checkpoint,Cell Cycle/Checkpoint

Target:

FLT,FLT,VEGFR,VEGFR,c-RET,c-RET,Src,FGFR,Aurora Kinase,Aurora Kinase,Src,FGFR,c-Fms,Chk,CDK