Bioactivity:

SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling. SPP-86 also inhibits RET-induced estrogen receptor_ phosphorylation in MCF7 cells. SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine ki

CAS nr:

1357349-91-7

Purity:

98%

Molecular Weight:

277,32

SMILES:

CC(C)N1C2=NC=NC(N)=C2C(C#CC3=CC=CC=C3)=N1

Formula:

C16H15N5

Pathway:

Tyrosine Kinase/Adaptors,Apoptosis

Target:

c-RET,c-RET