Bioactivity:

IN-1130 is a highly selective inhibitor of transforming growth factor-_ type I receptor kinase (ALK5) (IC50: 5.3 nM for ALK5-mediated Smad3 phosphorylation). IN-1130 inhibits ALK5 phosphorylation of casein (IC50: 36 nM) and p38_ mitogen-activated protein

CAS nr:

868612-83-3

Purity:

98%

Molecular Weight:

420,47

SMILES:

O=C(N)C1=CC=CC(CC2=NC(C3=NC(C)=CC=C3)=C(C4=CC=C5N=CC=NC5=C4)N2)=C1

Formula:

C25H20N6O

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

ALK,ALK