Bioactivity:

BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-_ (A_; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG inhibition and P-gp efflux.

CAS nr:

T10453

Purity:

98%

Molecular Weight:

461,41

SMILES:

O=C(C1=NC=C(OCF)N=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)S[C@H](C(F)(F)F)C3)=C2

Formula:

C18H16F5N5O2S

Pathway:

Neuroscience,Neuroscience

Target:

Beta Amyloid,BACE