Bioactivity:

Pladienolide B causes apoptosis. Pladienolide B is an effective cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing.

CAS nr:

445493-23-2

Purity:

98%

Molecular Weight:

536,7

SMILES:

O=C1O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1

Formula:

C30H48O8

Pathway:

Others

Target:

Others