Bioactivity:

JH-VIII-157-02 is a structural analogue of alectinib. This acts as an ALK inhibitor and displays an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

CAS nr:

1639422-97-1

Purity:

98%

Molecular Weight:

465,55

SMILES:

O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1

Formula:

C28H27N5O2

Pathway:

Others

Target:

Others