Bioactivity:

GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (Ki: 0.09 nM). The correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects decreases cytotoxicity.

CAS nr:

1705602-02-3

Purity:

98%

Molecular Weight:

515,58

SMILES:

O=C(C1=NNC2=C1C[C@H](C3(F)F)[C@@]3(C)C2)NC4=CN([C@H](C5=CC=CC=C5)[C@@H]6S(CCCC6)(=O)=O)N=C4

Formula:

C25H27F2N5O3S

Pathway:

Others

Target:

Others