Bioactivity:

GSK046 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins(IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively). It has immunomodulatory activity.

CAS nr:

2474876-09-8

Purity:

98%

Molecular Weight:

414,48

SMILES:

O=C(N[C@@H]1CC[C@@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2

Formula:

C23H27FN2O4

Pathway:

Chromatin/Epigenetic

Target:

Epigenetic Reader Domain