Bioactivity:

VH-298 is a potent inhibitor of VHL that stabilizes HIF-_ and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-_ protein-protein interaction downstream of HIF-_ hydroxylation by PHD enzymes.

CAS nr:

2097381-85-4

Purity:

98%

Molecular Weight:

523,65

SMILES:

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)C=C1

Formula:

C27H30N5O4S

Pathway:

Others

Target:

Others