Bioactivity:

STL127705 is a inhibitor of Ku 70/80 heterodimer protein(Ku70/80-DNA interaction, with an IC50 of 3.5 _M). STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 _M).

CAS nr:

1326852-06-5

Purity:

98%

Molecular Weight:

437,42

SMILES:

O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O

Formula:

C22H20FN5O4

Pathway:

Others,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair

Target:

Others,DNA-PK,DNA-PK