Bioactivity:

PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2_ antagonist, which directly binds to the HIF-2_ PAS B domain (IC50: 6 nM).

CAS nr:

1672662-14-4

Purity:

98%

Molecular Weight:

419,32

SMILES:

N#CC1=CC(F)=CC(OC2=CC=C(S(=O)(C(F)F)=O)C3=C2CC(F)(F)[C@H]3O)=C1

Formula:

C17H10F5NO4S

Pathway:

Angiogenesis,Chromatin/Epigenetic,Metabolism,Chromatin/Epigenetic

Target:

HIF,HIF,HIF/HIF Prolyl-Hydroxylase,HIF/HIF Prolyl-Hydroxylase