Bioactivity:

NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 _M against PHGDH.

CAS nr:

1542213-00-2

Purity:

98%

Molecular Weight:

395,45

SMILES:

S=C(NC1=NC(C)=CC(C)=C1)N2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F

Formula:

C18H20F3N5S

Pathway:

Metabolism

Target:

Dehydrogenase